The Roscosmos State Corporation for Space Activities, commonly known as Roscosmos, is the governmental body responsible for the space science program of the Russian Federation and general aerospace research. Soyuz has many launch locations the Russian sites are Baikonur, Plesetsk and Vostochny however Ariane also purchases the vehicle and launches it from French Guiana.

The Baikonur Cosmodrome is a spaceport operated by Russia within Kazakhstan. Located in the Kazakh city of Baikonur, it is the largest operational space launch facility in terms of area. All Russian crewed spaceflights are launched from Baikonur.

The Soyuz 2.1A converted the flight control system from analog to digital, which allowed launch from fixed platforms. It also allowed big fairings and payloads. It is currently used for crewed Soyuz and Progress flights to the ISS.