The Roscosmos State Corporation for Space Activities, commonly known as Roscosmos, is the governmental body responsible for the space science program of the Russian Federation and general aerospace research. Soyuz has many launch locations the Russian sites are Baikonur, Plesetsk and Vostochny however Ariane also purchases the vehicle and launches it from French Guiana.

Plesetsk Cosmodrome is a Russian spaceport located in Mirny, Arkhangelsk Oblast, about 800 km north of Moscow and approximately 200 km south of Arkhangelsk. Originally developed as an ICBM site for the R-7 missile, it also served for numerous satellite launches using the R-7 and other rockets. Its high latitude makes it useful only for certain types of launches, especially the Molniya orbits, so for much of the site's history it functioned as a secondary location, with most orbital launches taking place from Baikonur, in the Kazakh SSR. With the end of the Soviet Union, Baikonur became a foreign territory, and Kazakhstan charged $115 million usage fees annually. Consequently, Plesetsk has seen considerably more activity since the 2000s.

The Soyuz 2.1A converted the flight control system from analog to digital, which allowed launch from fixed platforms. It also allowed big fairings and payloads. It is currently used for crewed Soyuz and Progress flights to the ISS.